Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock (LockA locked padlock) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Freedom 250 banner logo Join HHS in Celebrating Freedom 250
    • About HHS

      HHS is a U.S. executive department that touches the lives of nearly all Americans by protecting your rights, research, food safety, health care, aging, and much more.

      Explore About HHS
    • About the Department
      • Leadership
      • HHS Divisions
      • Organizational Chart
      • Priorities
      • Budget in Brief
      • Contact Us
    • Press Room
      • Press Releases
      • Request for Comment
      • Request for Interview
      • Connect on Social Media
      • HHS Live
      • Podcasts
    • Careers
      • Working at HHS
      • Opportunities for Attorneys
      • Join the Health Workforce
      • I am HHS
      • New Employee Orientation
      • Transportation Services
    • Standards and Compliance
      • Gold Standard Science
      • Accessibility
      • Plain Writing
      • Digital Communications Standards
      • Records Management
    • Accountability and Transparency
      • Freedom of Information Act (FOIA)
      • Open Government
      • No Fear Act
      • Privacy at HHS
  • RealFood.gov
  • MAHA
    • Programs & Services

      HHS is responsible for public health, health care, and human/social services for the United States of America. This includes administering over 100 programs and services.

      Explore Programs & Services
    • Health Care
      • Find a Health Center
      • Find an Indian Health Service Facility
      • Find Support for Mental Health, Drugs, or Alcohol
      • Find a Cancer Center
      • Dental Care Options
      • Telehealth
    • Health Insurance
      • Medicare – 65+ or With Disability
      • Medicaid - Low-Income, With Disability, or Pregnant
      • Children’s Health Insurance Programs (CHIP)
      • Find Health Insurance Coverage
      • Insurance Help for Mental Health and Substance Use
      • No Surprise Medicals Bills
    • Social Services
      • Programs for Children and Families
      • Programs for People with Disabilities
      • Programs for Older Adults
      • Resources for Caregivers
    • Public Health and Prevention
      • Emergency Preparedness and Response
      • Healthy Lifestyle
      • Mental Health and Substance Use
      • Food Safety and Nutrition
      • Drug and Product Safety
    • Health Research and Information
      • National Library of Medicine
      • Surgeon General Reports
      • Health Data
      • National Center for Health Statistics
      • Medline Plus
      • Clinical Research Studies
      • Volunteering to Participate in Research
    • Laws & Regulations

      HHS protects and helps you understand the laws and regulations, also known as "rules," that govern the nation. You also have the power to voice your opinion on these laws and regulations.

      Explore Laws & Regulations
    • Regulatory Information
      • What is a Rule?
      • Find Rules by Division
      • Comment on Open Rules
      • Suggest Deregulatory Actions
      • Understand Key Federal Laws
    • Civil Rights
      • Your Civil Rights
      • Civil Rights Laws Enforced by HHS
      • Health Information Privacy
      • Substance Use Disorder Patient Confidentiality
      • Conscience and Religious Freedom
    • Laws and Regulations by Topic
      • HIPAA Privacy Rule
      • Health Insurance Protections
      • Health IT Legislation
      • Food and Drug Safety
      • Public Health Emergencies
    • Human Research Protections
      • The Belmont Report
      • Regulations, Policy, and Guidance
      • Human Subjects Regulations (45 CFR 46)
      • Register IRBs and Obtain FWAs
      • Trainings, Tutorials, and Workshops
      • International Research
    • Complaints and Appeals
      • File a Medicare Complaint
      • File a HIPAA Complaint
      • File a Civil Rights Complaint
      • Appeal an Insurance Company Decision
      • Report Fraud, Waste, and Abuse to OIG
      • Report a Problem to the FDA
      • Report a Tip on the Chemical and Surgical Mutilation of Children
    • Grants & Contracts

      HHS gives the most money in grants of any federal agency in the U.S. Find out about our grants and how your organization can apply for them. We also provide information on how you can work with us and our support of small businesses.

      Explore Grants & Contracts
    • Grants
      • Get Ready for Grants Management
      • Grant Policies and Regulations
      • Research Grants and Funding from NIH
      • Search Grants.gov
      • Avoid Grant Scams
      • Contact HHS Grant Officials
    • Contracts
      • Get Ready to Do Business with HHS
      • Programs for Businesses
      • Contract Policies and Regulations
      • Search Opportunities on SAM.gov
      • Contact HHS Contracting Managers
    • Small Business
      • Contract Opportunities
      • Small Business Programs
      • Small Business Resources
      • Contact Small Business Staff
    • Radical Transparency

      HHS protects and helps you understand the laws and regulations, also known as "rules," that govern the nation. You also have the power to voice your opinion on these laws and regulations.

      Explore Radical Transparency
    • CDC’s ACIP Conflicts of Interest
    • Ending Anti-Semitism on College Campuses
    • Ending Wasteful Spending
    • Keeping Food Ingredients Safe
    • Chemical Contaminants Transparency Tool
  • About OHRP
  • Regulations, Policy & Guidance
  • Education & Outreach
  • Compliance & Reporting
  • News & Events
  • Register IRBs & Obtain FWAs
  • SACHRP Committee
  • International
  • About Research Participation
    • Informational Videos
    • Questions to Ask
    • Protecting Research Volunteers
      • Why Have Regulations to Protect Research Participants?
      • What Regulations Protect Research Participants?
      • Who Oversees the Regulations to Protect Research Participants?
      • Is All Human Research Regulated?
      • Who is Responsible for Protecting Research Participants?
    • Additional Resources
    • Printable Information Materials
  • Upcoming Educational Events
  • Past Educational Events
  • Revised Common Rule
  • Human Research Protection Training
    • Human Research Protection Foundational Training
    • Participant-Centered Informed Consent Training
    • Considerations for Reviewing Human Subjects Research
    • OHRP Webinars
    • Mini-Tutorials
  • Videos
  • Exploratory Workshop
    • 2024 (Human Research with AI)
    • 2023 (Psychedelics Research)
    • 2022 (Payment for Participation)
    • 2021 (Third-Party Research Risks)
    • 2020 (Single IRB)
    • 2019 (Privacy and Data Research)
    • 2018 (Informed Consent)
  • Luminaries Lecture Series
  • Human Research Protection Program (HRPP) Resources
  • Educational Collaboration with OHRP
    • Research Community Forums (RCFs)
    • Educational Workshops
      • OHRP Co-Sponsored Workshops
    • Speaking Engagements
  • Education & Outreach Archived Materials

All Videos

  • September 25, 2025

    Part 2—Innovations and Advances in Sickle Cell Disease Gene Therapies
  • September 18, 2025

    Part 1—Trust, Clinical Trials, and Transformative Therapies: Ethical Pathways in Gene Therapy and Sickle Cell Disease
  • November 27, 2024

    Webinar On Differing Approaches to Measuring and Ensuring IRB Effectiveness
  • August 26, 2024

    How to Submit a Complaint to OHRP? (4:06)
  • June 24, 2024

    What to Know about Conducting Research with HeLa Cell (1:17:25)
  • April 17, 2024

    The Principles of the Belmont Report and the Ethics of Human Research (1:17:52)
  • January 18, 2024

    A Brief Review of SACHRP (8:27)
  • December 11, 2023

    How Do I Review Thee? Let Me Count the Ways: The Types and Manners of IRB Review (47:25)
  • August 17, 2023

    The Who, What, Why, and Where of IRB Meetings and Membership (1:02:56)
  • August 14, 2023

    Unlocking the Mysteries of the §46.111 Criteria for IRB Approval of Research (1:01:29)
  • June 22, 2023

    Promoting Research Representation and Engagement Opportunities under the Common Rule (46:51)
  • April 18, 2023

    Overview of Compliance Oversight Assessments with OHRP (11:59)
  • March 30, 2023

    Respecting Persons – From Basic Requirements to Embracing Participant- Centered Informed Consent (1:01:29)
  • March 30, 2023

    Before Saying “I Do” to the Common Rule: Figuring out “Engagement” (1:04:01)
  • March 29, 2023

    Doing Research with Data and Biospecimens under the Common Rule Part 1 – What Researchers Should Know (1:18:42)
  • March 29, 2023

    Doing Research with Data and Biospecimens under the Common Rule Part 2 – How Does that Work with Repositories and Future Use? (1:02:26)
  • February 1, 2023

    What You Need to Know About FWAs and IRBs to Get Your Grant Money (45:29)
  • February 1, 2023

    How Do I Know if a Research Study is Human Subjects Research and What Does that Really Mean? (1:02:30)
  • July 7, 2022

    Nothing basic about it, but we’ll try to make it so – Common Rule ABCs with OHRP [Basics of the Common Rule #1] (34:23)
  • July 7, 2022

    What is research, what isn’t, and who is a human subject anyway? – Explaining Common Rule terms in plain language [Basics of the Common Rule #2] (39:24)
  • July 7, 2022

    The ABCs of 104: Understanding exemption categories [Basics of the Common Rule #3] (44:05)
  • December 10, 2021

    Review of the Federalwide Assurance Application Form and How to Complete it (14:14)
  • November 17, 2021

    What is Human Subjects Research? Part 2: What Investigators Should Know About IRB Review (1:46:23)
  • November 17, 2021

    OHRP: What is Human Subjects Research? Part 1: A Review of the Common Rule and Its Application (1:46:23)
  • November 10, 2020

    Reporting to OHRP (1): Unanticipated Problems (18:05)
  • November 10, 2020

    Reporting to OHRP (2): Non-compliance, Suspensions, and Terminations (9:24)
  • November 10, 2020

    Simplifying Informed Consent (with OHRP) (1:45:38)
  • April 28, 2020

    OHRP Guidance on Response to COVID-19 (52:46)
  • October 7, 2019

    Institutional Engagement in Human Subjects Research (21:58)
  • July 12, 2018

    What's New in Informed Consent: Revisions to the Common Rule (26:50)
  • July 10, 2018

    How to Obtain an Electronic Submission Number for FWAs is replaced with Assurance Process with OHRP (9:43)
  • June 22, 2018

    When Does the Common Rule Apply? Review of the Basics Under the Revised Rule (18:14)
  • June 22, 2018

    Overview of Changes to Exemptions in the Revised Common Rule (Focusing on Exemptions 1, 2, 3, and 5) (26:06)
  • June 22, 2018

    Regulatory Options for Secondary Research with Private Information and Biospecimens Part 1 (Including Discussion of Exemptions 4,7, 8) (24:59)
  • June 22, 2018

    Regulatory Options for Secondary Research with Private Information and Biospecimens Part 2 (16:02)
  • June 22, 2018

    Broad Consent in the Revised Common Rule (17:30)
  • June 22, 2018

    What’s New in IRB Review Under the Revised Common Rule (8:22)
  • October 25, 2017

    IRB Review Criteria (12:43)
  • October 25, 2017

    Part 3 – The Belmont Report: Basic Ethical Principles and their Application (26:49)
  • October 25, 2017

    Part 2 – Balancing Society’s Mandates: I.R.B. Review Criteria (34:17)
  • October 25, 2017

    Part 1 – Evolving Concern: Protection for Human Subjects (19:07)
  • October 18, 2017

    Quorum and Voting in IRB Meetings (22:16)
  • September 14, 2017

    How to Obtain an Electronic Submission Number for IRBs (9:49)
  • April 28, 2017

    Membership Requirements for Institutional Review Boards (IRB) (13:01)
  • February 13, 2017

    Prisoner Research 2: Considerations When a Subject Becomes a Prisoner (18:16)
  • February 13, 2017

    Prisoner Research 1: 45 CFR 46 Subpart C - Basics (16:23)
  • April 14, 2016

    What You Should Know About IRB Review of Research (54:54)
  • March 31, 2014

    The Research Clinic Trailer- Interactive Research Training (2:16)
  • November 20, 2013

    Biobanking: When Issues with Tissues Come a’Knockin’ (1:03:05)
  • March 28, 2013

    When the Assurance Comes A Knockin': OHRP's FWA and IRB Registration Processes (31:47)
  • November 8, 2012

    When PIs Come a'Knockin': Everything Investigators Want to Know but are Afraid to Ask (40:20)
  • September 21, 2010

    IRB Records, Part II (13:50)
  • September 21, 2010

    IRB Records, Part I (05:57)
  • September 21, 2010

    Complex Issues with Research Involving Vulnerable Populations (28:12)
  • August 24, 2010

    General Informed Consent Requirements (18:38)
  • July 5, 2010

    Research Use of Human Biological Specimens and Other Private Information (22:42)
  • July 5, 2010

    Institutional Review Board (IRB) Membership (16:04)
  • November 16, 2004

    Belmont Report 25th Anniversary Video Series (26:50)
  • Conducting Internet Research: Challenges and Strategies for IRBs (54:44)
Back to top
Secretary Robert F. Kennedy Jr.

Follow @SecKennedy

HHS icon

Follow @HHSGov

HHS Email updates

Receive email updates from HHS.

Subscribe

HHS Logo

HHS Headquarters

200 Independence Avenue, S.W.
Washington, D.C. 20201
Toll Free Call Center: 1-877-696-6775​

  • Contact HHS
  • Careers
  • HHS FAQs
  • Nondiscrimination Notice
  • Press Room
  • HHS Archive
  • Accessibility Statement
  • Budget/Performance
  • Inspector General
  • Web Site Disclaimers
  • EEO/No Fear Act
  • FOIA
  • The White House
  • USA.gov
  • Vulnerability Disclosure Policy