The National Vaccine Program identifies priorities that are central to improving the vaccination system in the United States. This work requires both focused attention and extensive coordination among federal and non-federal partners. The featured priorities listed below may change over time in step with changes in the immunization landscape. Our current featured priorities are: catch-up vaccination, adult immunization, vaccine confidence, HPV vaccination, vaccine safety, and vaccine innovation. Catch-Up Vaccination The COVID-19 pandemic has caused a significant decline in routine immunizations that occur during adult annual physical exams and children’s wellness visits. The makes the nation vulnerable to more vaccine-preventable illnesses, hospitalizations, and deaths. Learn more about our catch-up immunization efforts. Adult Immunization Vaccines are safe, effective, and widely available — but adult vaccination rates remain low in the United States. OIDP works with partners to improve adult vaccination rates. Learn more about adult immunization. HPV Vaccination Despite the availability of a safe and effective human papillomavirus (HPV) vaccine, not enough young people are fully vaccinated against HPV. This leaves them at risk for a number of cancers caused by HPV later in life. We work with vaccination and cancer prevention partners to strengthen HPV vaccination efforts across the nation. Learn more about HPV vaccination. Vaccine Confidence Public trust in vaccines is key to keeping our communities healthy. We work with partners to strengthen public trust in vaccines. Learn more about vaccine confidence. Vaccine Innovation The U.S. vaccine enterprise is well established and has been successful at bringing innovative and new and improved vaccines to the market. However, challenges to innovation have increased for remaining infectious disease targets. We work with partners to support vaccine innovation. Learn more about vaccine innovation. Vaccine Safety The continued success of vaccines depends on a strong vaccine safety system. We work with partners to support vaccine safety monitoring and research. Learn more about vaccine safety.