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  1. Home
  2. National Opioids Crisis: Help and Resources
  3. Preventing Opioid Use, Misuse, and Overdose
  • Opioids: Help and Resources
    • Prevention
      • How to Safely Dispose of Drugs
      • Pain Management Options
      • Safe Opioid Prescribing
      • Prevention Programs and Tools
    • Treatment
      • How Do Medications Treat Opioid Addiction?
      • Does Insurance Cover Treatment for Opioid Overdose?
      • How to Respond to an Opioid Overdose
      • What Are Drug Courts?
      • Resources for Opioid Treatment Providers
    • Recovery
    • Facts and Statistics

Preventing Opioid Use, Misuse, and Overdose

When used correctly under a health care provider's direction, prescription pain medicines are helpful. However, misusing prescription opioids risks dependence and overdose.

The best ways to prevent opioid overdose deaths are to improve safe opioid prescribing, reduce exposure to opioids, prevent misuse, and treat opioid use disorder (OUD).

What are opioids?

Opioids are a class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine, morphine, and many others.

Prescription opioids

Opioids are a class of drugs naturally found in the opium poppy plant. Some prescription opioids are made from the plant directly, and others are made by scientists in labs using the same chemical structure.

  • If you take a medicine in a way that is different from what the doctor prescribed, it is called prescription drug misuse.
  • Prescription opioid use, even when used as prescribed by a doctor can lead to opioid use disorder (OUD).
  • Misuse of Prescription Drugs Research Report

Fentanyl

Fentanyl is a powerful synthetic opioid that is similar to morphine but is 50 to 100 times more potent. In its prescription form it is prescribed for pain, but fentanyl is also made illegally.

  • A Patient’s Guide to Fentanyl

Heroin

Heroin is a highly addictive drug made from morphine, which comes from opium poppy plants. Some prescription opioid pain medicines have effects similar to heroin. Research suggests that misuse of these drugs may open the door to heroin use.

  • Medical Facts About Heroin
  • Prescription Opioids and Heroin Research Report

Need help?

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SAMHSA National Helpline

Get treatment referral and information about mental health and drug or alcohol use disorders, prevention, and recovery.

Call 1-800-662-4357
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FindTreatment.gov

Millions of Americans have mental and substance use disorders. Find a comprehensive list of certified treatment programs across the United States.

Find treatment near you
Content last reviewed January 23, 2026
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