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- Administration for Strategic Preparedness and Response (ASPR)
- Office of Administration
- Head of Contracting Activity*
- Finance
- Human Capital
- Information Technology
- Office of Preparedness
- Health Care Readiness
- Medical Reserve Corps
- Security and Intelligence
- Information Management Data and Analytics
- Critical Infrastructure Protection
- Planning and Exercises
- Continuity
- Secretary's Operations Center
- Office of Response
- National Disaster Medical System
- Regional Response
- Response Logistics
- Community Mitigation and Recovery
- Biomedical Advanced Research and Development Authority (BARDA)
- Medical Countermeasures Program Support Services (MCPSS)
- Medical Countermeasures Program (MCMP)
- Deputy Head of Contracting Activity
- Office of Industrial Base Management and Supply Chain
- PPE and DME
- Testing and Diagnostics
- Advanced Manufacturing Technologies
- Supply Chain Optimization
- DPA and Emergency Response Authorities
- Strategic National Stockpile
- Management and Business Operations
- Logistics
- State Tribal Local and Territories Preparedness
- National Readiness and Response
- Supply Chain Alliance and Development
- Science
- HHS Coordination Operations and Response Element
- Supply, Production, and Distribution
- Planning and Operational Coordination
- Operations Technical Assistance
- Analytics, Data, and IT*
- Security and Assurance*
- Office of Administration
Note: Offices marked with an asterisk (*) report to multiple parts of the organization. Within the Office of Administration, the Deputy Head of Contracting Activity is also part of BARDA. Within H-CORE, the Office of Analytics and the Office of Security and Assurance are part of the Office of Preparedness but provide support to H-CORE