HHS Unveils AI Strategy to Transform Agency Operations

WASHINGTON — December 4, 2025 — The U.S. Department of Health and Human Services (HHS) today released its AI Strategy, the next phase of the Department's transformative initiative to make artificial intelligence (AI) available to the federal workforce, integrating it across internal operations, research, and public health. It fulfills HHS' commitment to utilize leading technologies to enhance efficiency, foster American innovation, improve patient outcomes, and Make America Healthy Again.

"AI has the potential to revolutionize health care and human services, and HHS is leading that paradigm shift," said Deputy Secretary of Health and Human Services Jim O'Neill. "By guiding innovation toward patient-focused outcomes, this Administration has the potential to deliver historic wins for the public—wins that lead to longer, healthier lives."

Led by the HHS Acting Chief Artificial Intelligence Officer Clark Minor, the HHS AI Strategy delivers on the Trump Administration's AI Action Plan, AI-related Executive Orders, and guidance from the Office of Management and Budget (OMB). Keeping pace with the rapid evolution of AI technologies, the five Pillars of HHS' AI Strategy will be revisited and updated as necessary to optimize AI technologies' impact across the Department. These Pillars are:

• Ensure governance and risk management for public trust.
• Design infrastructure and platforms for user needs.
• Promote workforce development and burden reduction for efficiency.
• Foster health research and reproducibility through gold standard science.
• Enable care and public health delivery modernization for better outcomes.

"AI is a tool to catalyze progress," said Acting Chief Artificial Intelligence Officer Clark Minor. "This Strategy is about harnessing AI to empower our workforce and drive innovation across the Department."

"Artificial intelligence has enormous potential to strengthen our nation's health-care system," said Rep. Jay Obernolte (R-CA), Chairman of the Bipartisan House Task Force on Artificial Intelligence. "I'm encouraged that HHS is taking a thoughtful, outcomes-driven approach that prioritizes transparency, rigorous risk management, public trust, and respect for Americans' health data."

"I commend Secretary Kennedy and the HHS team for developing this strategy to utilize AI technologies and better serve taxpayers," said Sen. Todd Young (R-IN), Member of the Senate Artificial Intelligence Working Group. "This is the kind of innovative leadership that will help restore faith in government and improve health outcomes across America."

"Artificial Intelligence offers a revolutionary opportunity to strengthen American health care through faster, more accurate diagnoses, improved patient access, lower costs and cures to many of the diseases Americans face today," said Senator Mike Rounds (R-SD), Co-Chair of the Senate Artificial Intelligence Caucus. "President Trump's Department of Health and Human Services clearly recognizes this potential."

For the first time in the Department's history, this Strategy's "OneHHS" approach invites all HHS divisions—including the Centers for Disease Control and Prevention (CDC), the Centers for Medicare & Medicaid Services (CMS), the Food and Drug Administration (FDA), the National Institutes of Health (NIH), and others—to collaborate in the development of one robust Department-wide AI infrastructure, streamlining workflows and enhancing cybersecurity.

HHS' AI Strategy does not encompass the Department's complete vision for integrating AI into the delivery of its services. It is the first step, focused primarily on improving internal operations, efficiency, and federal use as directed by OMB. It also paves the way for engagement with private sector stakeholders to co-create solutions that maximize the potential of AI.