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MM12928 - National Coverage Determination 110.24: Chimeric Antigen Receptor T-cell Therapy

This revised Article comprises Subregulatory Guidance for CAR T-cell Therapy (CAR-T) billing to include additional place of service (POS) codes for office and independent clinics, bill in 0.1-unit fractions, don’t bill more than 1 unit per HCPCS code and use 3 modifiers, including new modifier -LU. In this case, this article is based on content within CR12928 that is posted on the CMS website at

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Issued by: Centers for Medicare & Medicaid Services (CMS)

Issue Date: January 05, 2023

DISCLAIMER: The contents of this database lack the force and effect of law, except as authorized by law (including Medicare Advantage Rate Announcements and Advance Notices) or as specifically incorporated into a contract. The Department may not cite, use, or rely on any guidance that is not posted on the guidance repository, except to establish historical facts.