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HHS Guidance Portal

The Guidance Portal is a public website that shows current guidance documents from the U.S. Department of Health and Human Services (HHS) and its Divisions.

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HHS Guidance Documents
Title OpDiv/StaffDiv Guidance Status Issue Date
Clostridioides difficile Infection: Developing Drugs for Treatment, Reduction of Recurrence, and Prevention  Food and Drug Administration (FDA) Final
Patient-Matched Guides for Orthopedic Implants: Guidance for Industry and Food and Drug Administration Staff  Food and Drug Administration (FDA) Final
2026 Middle East Repatriation Policy Letter  Administration for Children and Families (ACF) Final
Submitting Continuous Glucose Monitoring Data in Clinical Trials  Food and Drug Administration (FDA) Final
Updated National Model Foster Family Home Licensing Standards, Kin-Specific Foster Family Home Licensing Standards, and Updates to the Responsibilities and Recommendations for Licensing Agencies  Administration for Children and Families (ACF) Final
ACF-OCS-LIHEAP-AT-2026-03 LIHEAP Federal Fiscal Year 2026 (FY26) Quarterly Report Submission  Administration for Children and Families (ACF) Final
Chemistry, Manufacturing, and Controls Flexibilities for Developing Human Cellular and Gene Therapy Products for a Biologics License Application: Guidance for Industry  Food and Drug Administration (FDA) Final
FFY 2027 Updates to the Health Home Core Quality Measure Sets  Centers for Medicare & Medicaid Services (CMS) Final
Updated 2026 Supplemental Security Income (SSI) and Spousal Impoverishment Standards  Centers for Medicare & Medicaid Services (CMS) Final
Dear Child Welfare Director Letter on Updated Guidance for the Next Annual Progress and Services Report  Administration for Children and Families (ACF) Final
This Guidance Portal contains 11397 documents.