HHS Announces Request for Information to Harness Artificial Intelligence to Deflate Health Care Costs and Make America Healthy Again

HHS to use regulation, reimbursement, and research & development levers to enable AI adoption and use in clinical care to evolve and propel the US health care system forward

Today, advancing President Trump’s commitment to ensuring American leadership in Artificial Intelligence (AI) and Secretary Kennedy’s vision to Make America Healthy Again, the U.S. Department of Health and Human Services (HHS) announced the release of a Request for Information (RFI) seeking broad public input on how HHS can accelerate the adoption and use of artificial intelligence as part of clinical care for all Americans.

Through this RFI, HHS is inviting stakeholders to provide feedback on how the Department can use its regulatory, reimbursement, and research & development levers across all of HHS to enable AI adoption to propel the American health care system forward.

The HHS Office of the Deputy Secretary—which leads the Department’s AI strategy— seeks broad engagement on how HHS can accelerate adoption, including how AI can improve patient and caregiver experiences and outcomes, reduce provider burden and improve quality of care, and reduce health care costs for consumers and government.

“Artificial intelligence will be a transformative force for good across America.” said HHS Deputy Secretary Jim O’Neill. “We want to hear from you. Our efforts to accelerate AI adoption must be guided by the real needs and experiences of those developing these tools and delivering care.”

As AI-driven technologies continue to advance, HHS is focused on interoperability and ensuring that patient data is safe, secure, and only used as allowed under HIPAA. “Artificial intelligence is powered by data. Data liquidity and the trust patients and providers have in how data moves are essential,” said Dr. Thomas Keane, MD, MBA, Assistant Secretary for Technology Policy and National Coordinator for Health IT. “Through our interoperability work, we are designing for both, bringing true data access to patients and enabling AI. We look forward to hearing how these tools can best strengthen care.”

HHS seeks broad public engagement and response to how HHS can accelerate the adoption and use of AI as part of clinical care. This includes input on how digital health and software regulatory frameworks should evolve to account for AI-driven tools while maintaining patient safety; how reimbursement structures can be simplified and better aligned to support the use of efficient, deflationary technologies; and how research and development investments can strengthen implementation science and best practices, especially for complex or high-acuity clinical scenarios.

HHS also encourages future-looking responses that focus on medium- and long-term trends and needs that face the health care system, including addressing conditions that will emerge or continue to increase in prevalence, such as frailty or dementia. The responses will inform the critical, coordinated activities that will drive enabling change across all HHS divisions.

Today’s announcement complements the HHS AI Strategy—which focuses on the Department’s internal efforts to harness AI and embed it across HHS operations—by extending that “OneHHS” approach outward to accelerate AI adoption across the health care system.

For more information or to respond to HHS’s RFI on accelerating the adoption and use of Artificial Intelligence as part of clinical care, please visit: https://www.federalregister.gov/public-inspection/2025-23641/request-for-information-accelerating-the-adoption-and-use-of-artificial-intelligence-as-part-of