As part of its mission to improve the health of the American people, HHS invests in each step of the process that starts with basic scientific discovery and ends with the development and provision of better diagnostics, treatments, and preventive strategies to significantly improve patient care. These steps can be very complex, which can mean that promising scientific discoveries move quite slowly toward practical application as a new diagnostic, treatment, or proven prevention regimen. The good news is that HHS has learned what problems can arise in this process and has begun to develop solutions. The Department has identified the steps necessary to advance scientific breakthroughs to improve patient care.
- Accelerate Biomedical Discovery through Innovation
HHS will accelerate biomedical discovery through innovative methodologies and technology. HHS will continue to support fundamental discoveries that expand the knowledge base in the biomedical and behavioral sciences. Also of critical importance is ongoing cross-agency development of information systems capable of storing, organizing, and sharing vast amounts of data with researchers around the globe, which will accelerate scientific discovery.
- Enable Efficient Regulatory Review
HHS will facilitate fast-tracking of medical innovations to integrate biomedical research planning and regulatory review. HHS also will support training of regulatory scientists to develop the skills necessary to integrate research planning and regulation of resulting biomedical products. HHS will develop cross-agency initiatives to support regulatory science to enhance the safety, quality, and efficiency of clinical research and medical product approval.
- Efficiently Translate Novel Research Discoveries into Therapies
HHS is exploring new partnerships that can help academic investigators to translate basic science into new therapies—effectively “de-risking” projects for commercial development. HHS is providing researchers with large-scale screening resources to facilitate identification of small molecules that may have activity against a disease target. HHS is also providing resources for preclinical evaluation of promising therapeutics and is building a national network of clinical research centers to enable clinical trials of promising compounds.
- Support the Science of Health Care Reform
HHS supports patient-centered research to identify high-quality, high-value drugs, surgeries, and other treatment options. HHS also supports research on personalized medicine, behavioral science, health economics, and health disparities, and will conduct health services research, an essential facet of a complete evidence-based health care system. By examining and enhancing the most effective ways to integrate preventive, screening, diagnostic, and treatment health services into community practice, HHS further supports more effective individualized prevention efforts, as well as methods to deliver the right care to the right patient at the right time, regardless of race, ethnicity or socioeconomic status.
- Disseminate Health Information to the Public
HHS will develop a comprehensive plan for more effectively disseminating health information to the public. Importantly, HHS will carefully examine the effectiveness of information tailored to underserved populations, which often have greater risk of certain diseases and conditions. HHS will ensure that information reaches underserved populations to improve health status.