Effects of a Single Dose of Dextroamphetamine in Attention Deficit
Hyperactivity Disorder: A Functional Magnetic Resonance Study
National Institute of Mental Health
The above-referenced research protocol proposes to study the effects of a single 10 mg dose of dextroamphetamine in conjunction with functional magnetic resonance imaging in healthy children and children with attention deficit hyperactivity disorder (ADHD), all between 9 and 18 years of age. The overall goal of the proposed study is to better understand the pathophysiology of ADHD. The specific aims of the study are to: (i) study brain activation patterns during response inhibition tasks in children with ADHD and in healthy controls; (ii) simultaneously examine the central and behavior effects of a single-dose of amphetamine versus placebo in the two groups; and (iii) examine (using monozygotic and dizygotic twins) brain activation patterns in relation to clinical state and the degree of genetic relatedness.
National Institute of Mental Health, National Institutes of Health